Holden eader text

Student Authored Publications

32. Investigation of the enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-glucuronic acid in Psychrobacter cryohalolentis K5T. Hofmeister, D. L., Seltzner, C. A., Bockhaus, N. J., Thoden, J. B., and Holden, H. M. (2023) Protein Science, 32:e4502.

31. Structure and function of an N-acetyltransferase from the human pathogen Acinetobacter baumannii isolate BAL_212. Herkert, N. R., Thoden, J. B., Holden, H. M. (2022) Proteins, 90(8):1594-1605.

30. Biochemical investigation of an N-acetyltransferase from Helicobacter pullorum. Griffiths, W. A., Spencer, K. D., Thoden, J. B. and Holden, H. M. (2021) Protein Science, 30, 2418-2432.

29. Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis. Heisdorf, C. J., Griffiths, W. A., Thoden, J. B., and Holden, H. M. (2021) Protein Science, 2144-2160.

28. Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus. Seltzner, C. A., Ferek, J. D.,Thoden, J. B., and Holden, H. M. (2021) Protein Science, (2021), 1882-1894.

27. Biosynthesis of D-glycero-L-gluco-heptose in the capsular polysaccharides of Campylobacter jejuni. Huddleston, J. P., Anderson, T. K., Girardi, N. M., Thoden, J. B., Taylor, Z., Holden, H. M., and Raushel, F. M. (2021)  Biochemistry, 60, 1552-1563.

26. Characterization of two enzymes from Psychrobacter cryohalolentis that are required for the biosynthesis of an unusual diacetamido-D-sugar. Linehan, M. P., Thoden, J. B., and Holden, H. M. (2021) Journal of Biological Chemistry 296, 100463.

25. The high-resolution structure of a UDP-L-rhamnose synthase from Acanthamoeba polyphaga Mimivirus. Bockhaus, N. J., Ferek, J. D., Thoden, J. B., and Holden, H. M. (2020) Protein Science, 29, 2164-2174.

24. Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga MimivirusFerek, J. D., Thoden, J. B., and Holden, H. M. (2020) Protein Science, 29, 1148-1159.

23. Misannotations of the genes encoding sugar N-formyltransferases. Girardi, N. M., Thoden, J. B., and Holden, H. M. (2020) Protein Science, 29, 930-940.

22. Structural and functional characterization of YdjI, an aldolase of unknown specificity in Escherichia coli K12. Huddleston, J. P., Thoden, J. B., Dopkins, B. J., Narindoshvili, T., Fose, B. J., Holden, H.M., and Raushel, F. M. (2019) Biochemistry, 58, 3340-3353.

21. Investigation of a sugar N‑formyltransferase from the plant pathogen Pantoea ananatis. Hofmeister, D. L., Thoden, J. B., and Holden, H. M. (2019) Protein Science, 28, 707-716.

20. The three-dimensional structure of NeoB: an aminotransferase involved in the biosynthesis of neomycin. Dow, G. T.,Thoden, J. B., and Holden, H. M. (2018) Protein Science, 27, 945-956.

19. Molecular architectures of Pen and Pal: key enzymes required for CMP-pseudaminic acid biosynthesis in Bacillus thuringiensis. Delvaux, N. A., Thoden, J. B., and Holden, H. M. (2018) Protein Science, 27, 738-749.

18. Structural and biochemical investigation of PglF from Campylobacter jejuni reveals a new mechanism for a member of the short chain dehydrogenase/reductase superfamily. Riegert, A. S., Thoden, J. B., Schoenhofen, I. C., Watson, D. C., Young, N. M., Tipton, P. A., and Holden, H. M. (2017) Biochemistry, 56, 6079-6082.

17. The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin. Zachman-Brockmeyer, T. R., Thoden, J. B., and Holden, H. M. (2017) Protein Science, 26, 1886-1892.

16. Biochemical investigation of Rv3404c from Mycobacterium tuberculosis. Dunsirn, M. M., Thoden, J. B., Gilbert, M., and Holden, H. M. (2017) Biochemistry, 56, 3818-3825.

15. Biochemical characterization of WbkC, an N-formyltransferase from Brucella melitensis. Riegert, A. S., Chantigian, D. P., Thoden, J.B., Tipton, P. A., and Holden H. M. (2017) Biochemistry, 56, 3657-3668.

14. Molecular architecture of an N-formyltransferase from Salmonella enterica O60. Woodford, C. R., Thoden, J. B., and Holden, H. M. (2017) Journal of Structural Biology, 200, 267-278.

13. Structural investigation of WlaRG from Campylobacter jejuni: a sugar aminotransferase. Dow, G. T., Gilbert, M., Thoden, J. B., and Holden, H. M. (2017) Protein Science, 26, 586-599.

12. Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116. Li, Z. Z., Riegert, A. S., Goneau M. F., Cunningham, A. M., Vinogradov, V., Li, J., Schoenhofen, I. C., Thoden, J. B., Holden, H. M., and Gilbert, M. (2016) Glycobiology, 27, 358–369.

11. Structural studies on KijD1, a sugar C-3′ methyltransferase. Dow, G. T., Thoden, J.B., and Holden, H. M. (2016) Protein Science, 25, 2282-2289.

10. Structural studies on a glucosamine/glucosaminide N-acetyltransferase. Dopkins, B. J., Tipton, P. A., Thoden, J. B., and Holden, H. M. (2016) Biochemistry, 55, 4495-4508.

9. Structures of KdnB and KdnA from Shewanella oneidensis: key enzymes in the formation of 8-amino-3,8-dideoxy-D-manno-octulosonic acid. Zachman-Brockmeyer, T. R., Thoden, J. B. and Holden, H. M. (2016) Biochemistry, 55, 4485-4494.

8. Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N5-formyltetrahydrofolate and UDP-Ara4N. Genthe, N. A., Thoden, J. B., and Holden, H. M. (2016), Protein Science, 25, 15555-1562.

7. Molecular architecture of KedS8, a sugar N-methyltransferase from Streptoalloteichus sp. ATCC 5650. Delvaux, N. A.,Thoden, J. B., and Holden, H. M. (2015), Protein Science, 24, 1593-1599.

6. Structure of the external aldimine form of PglE, an aminotransferase required for N,N’-diacetylbacillosamine biosynthesis. Riegert, A. S., Young, N. M., Watson, D. C., Thoden, J. B., and Holden, H. M. (2015) Protein Science, 24, 1609-1616.

5. Molecular structure of an N-formyltransferase from Providencia alcalifaciens O30. Genthe, N. A., Thoden, J. B., Benning, M. M., and Holden, H. M. (2015) Protein Science, 24, 976-986.

4. A new role for the ankyrin repeat revealed by the study of the N-formyltransferase from Providencia alcalifaciens. Woodford, C. R., Thoden, J. B., and Holden, H. M. (2015) Biochemistry, 54, 631-638.

3. Three-dimensional structure of a sugar N-formyltransferase from Francisella tularensis. Zimmer, A. L., Thoden, J. B., and Holden, H. M. (2014) Protein Science, 23, 273-283.

2. Structural and biochemical characterization of a bifunctional ketoisomerase/N-acetyltransferase from Shewanella denitrificans. Chantigian, D. P., Thoden, J. B., and Holden, H. M. (2013) Biochemistry, 52, 8374-8385.

1. Active site architecture of a sugar N-oxygenase. Thoden, J. B., Branch, M. C., Zimmer, A. L., Bruender, N. A., and Holden, H. M. (2013) Biochemistry, 52, 3191-3193.